The phrase "a well established activity" is correct and usable in written English.
It can be used to describe an activity that is recognized and accepted as being established or traditional within a certain context.
Example: "Gardening is a well established activity that promotes mental well-being and physical health."
Alternatives: "a widely recognized activity" or "a firmly rooted activity."
A promising candidate for a combined radiochemotherapy seems to be topotecan, a topoisomerase I inhibitor with a well established activity in the systemic treatment of SCLC (von Pawel et al, 1999) and NSCLC (Stewart, 2004), a high brain capillary permeability (Sung et al, 1994; Baker et al, 1996) and radiosensitising effects (Kim et al, 1992; Lamond et al, 1996).
Firstly, in current literature it is not recommended for the specific use of collect samples for the detection of Mycobacterium tuberculosis (MTB) in children [ 18]; secondly, local anesthetics have a well established antimicrobial activity versus bacteria and fungi [ 33- 35].
c-Fos is a well established marker of neuronal activity that has been widely used to show neuronal groups activated by nociceptive inputs [52].
Interestingly, we also observed significantly reduced DNA binding of NF-κB subunits in HIF-1α-deficient cells after stimulation with TNFα, a well established inducer of NF-κB activity [44].
There is, however, a well established relation between increasing physical activity and health benefit, so showing a small increase across a population has health benefits and can be cost effective considering the low cost of the intervention.
Reduced physical activity is a well established risk factor for both diabetes and prediabetes [ 26], but moreover, could also contribute to an accelerated conversion rate from prediabetic states to DM [ 26].
Differentiation of rat adrenal pheochromocytoma (PC12) cells is accompanied by neurite outgrowth, which serves as a well established and sensitive measure for Ras/MAPK activity (Gorfe et al., 2007).
It is a well established fact that chromosomal regions change their activity in diseases that harbor copy number alterations, such as some cancers [ 6].
In turn, FGF signaling is capable to create an autocrine feedback using cell surface receptors that feed into the MAPK pathway, and FGF activity is indeed a well established modulator of ES cell heterogeneity [ 18].
Although Dr Venter is turning such bioprospecting from a sport using a fishing line to one using a trawling net, looking for new bacteria is already a well-established activity.
It is well established GPx activity parallels serum selenium levels [ 50, 51] and selenium deficiency is associated with subnormal levels of selenoproteins [ 52].
