We also identified Beta3 and mist genes in Platynereis, but these genes were not further characterized as their Drosophila and vertebrate orthologs do not have well defined functions in neurogenesis.
The roles of several genes with well defined functions in pancreatic development, such as those mentioned above (Hlxb9, Hes-1 and Neurod) have not been previously studied in the adult pancreas.
Genes involved in levels S, T and B of the genetic network underlying a single signaling pathway have different but well defined functions, as briefly described above.
Such clusters of densely interconnected nodes combine in an overlapping manner, share well defined functions and hubs as the modules connectors [ 1, 3, 4].
Twenty-three genes had well defined functions, including four that were involved in metabolism and 12 that played roles in cellular processes, signalling and transport.
The residues for which a defined function in ribosome rescue was assigned in the well-studied E. coli tmRNA presented strong conservation (Fig. 4).
Such mutations are neutral in the sense of Wagner's definition: "A neutral mutation does not change a well defined aspect of a biological system's function in a specific environment and genetic background [ 36]." It is implicit in this definition that neutral mutations may aquire a phenotypic signature if the system conditions change.
This model is linked to a mathematical optimisation algorithm in order to enable the optimisation of vehicle design parameters through the minimisation of a well defined objective function.
She represented Eichmann as a colourless bureaucrat performing a well-defined function in an impersonal bureaucratic machine; but the Nazi state was in fact largely chaotic, with different institutions, departments of government and individuals competing for Hitler's favour.
This family contains four members, EGFR, ErbB2/human epidermal growth factor receptor-2 (HErbB3/HER33/HER3, and ErbB4/HER4, that act as receptor tyrosine kinases and have a well-defined function in cell signaling, controlling cell proliferation and differentiation.
The solution requires an algorithm that finds the maximum value of the objective function in a well defined variable space.
