Partial validation and observed well defined expression patterns suggest that a considerable fraction of these signals might represent bona-fide unannotated antisense transcripts (both cis- and trans).
Well defined expression windows of myogenic and growth-related genes during Senegalese sole ontogeny and larval development have been previously characterised, since different genes are activated or down-regulated at different stages of development [ 23, 32].
The MCF10AT1 cell line was chosen based on its known background of Ha-ras mutation as the genetic risk factor introduced to the non-transformed MCF10A line, and its ability to be transformed into a variety of a carcinomas when they were xenographed into the breast fat pad of nude mice [ 13, 14] as well as its well defined expression of both the estrogen and c-Neu receptors.
While the presence in our sample of both unsporulated and sporulated oocysts hampered the association of protein expression with a well defined oocyst maturation stage, it enabled the proteomic sampling of a wider range of proteins, including those expressed exclusively, or more abundantly, prior to sporulation.
Using random in-silico networks to generate simulated gene expression data from a well defined network structure allowed systematic evaluation of the algorithm.
Next, we questioned whether tissue-specific expression of imprinted genes is regulated by a well defined set of transcription factors.
Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form.
The meaning of a derived analytical expression giving the critical solids flux as a function of a well defined relationship between the underflow concentration and the solids load in a continuous thickener at optimal load is discussed.
Because the analytical expressions for the full molecular weight distribution (MWD) as well as the fractional MWDs containing 0, 1, 2, etc., branch points can be determined, such polymer molecules are regarded as polymers with a well defined branched structure.
A defining feature of most ukiyo-e prints is a well defined, bold, flat line.
Is there a well defined question?
