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As we predicted a net reduction of excitability by Mg++ based on our survival studies, we compared the effects of escalating concentrations of tetrodotoxin (TTX), a highly selective antagonist of voltage-gated sodium channels with well defined effects on excitability.
RNI 249 is also likely to be orally active in terms of enhanced IGF-1 production as it is orally active for anabolic actions in farmed fish (unpublished observations) and Lepidium meyenii and related extracts have well defined effects in pregnancy and male fertility upon oral administration [ 48- 51]; effects that are entirely consistent with enhanced IGF-1 production.
Thus, it appears that the GAG loses its effect only below a well defined threshold, when the excessively small length of the polysaccharide chain suppresses the macromolecular nature of the GAG.
Atomic force microscopy based microwear experiments allow deeper understanding of mechanisms of wear on the microscopic scale due to a well defined single asperity contact, elimination of roughness effects, and the high lateral and vertical resolution in the micro- and nanometer range.
The paper of Nodari [ 1] nicely demonstrates that the effect of fish oil can be best studied in a well defined patient population.
Compared with the effects of HBx on HIF-1 α, a similar tendency of changes in NF- κB, a well defined target of HBx, was also observed.
In both cases, a well defined electrochemical response was observed.
A defining feature of most ukiyo-e prints is a well defined, bold, flat line.
Is there a well defined question?
Direct thrombin inhibitors have a well defined mechanism of action.
For instance, RFX1 contains a well defined AD [ 16].
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