Sentence examples for a weaker affinity than from inspiring English sources

Because phytoestrogens structurally resemble estrogen, these compounds may exert their effects primarily through binding to ER, although usually with a weaker affinity than endogenous estrogens [ 46].

Compound 7 with a p-CF3 substituent binds to all three IAP proteins with a weaker affinity than 2 but shows a selectivity of 933 times for cIAP1 over XIAP.

The conclusion of these studies is that organofluorines are able to act as HB acceptors, albeit with a weaker affinity than the usual oxygen- and nitrogen-based HB acceptors.

GRIA1Asn has a weaker affinity to glutamate than GRIA1Ser, both in Xenopus oocytes and in the membrane fraction of bovine brain.

This is not the case for HMA6 which displays almost no phosphorylation from ATP in the presence of contaminant Cu+, suggesting that HMA6 has a weaker affinity for Cu+ than HMA8.

These data are in contrast with previous results showing that Imp-βKetD might have a weaker affinity toward RanGTP than Imp-β (Timinszky et al. 2002), but as is shown in the upper panels, we used equal amounts of Imp-β proteins in the reaction mix.

Intriguingly, we found that Walker A mutants bind MANT-ATP with only a twofold weaker affinity than wild type RIG-I when stimulated by the 5′ppp10L RNA.

BPA has a low affinity for ER-β, as described in several models, with a 1,000-fold 1,000-foldinity than E2, and activates pancreatic islet, hypophysial, or endometrial cells through an ncmER (Alonso-Magdalena et al. 2005; Bulayeva and weaker 2004; Naffinityal. 2000; Noguchi ethan. 2002).

In contrast, this trend was not observed for imipenem, where GES-5 exhibited a weaker affinity for this carbapenem than GES-2.

51, 86 It has been proposed that nilotinib is associated with less fluid retention because it has a weaker affinity for platelet-derived growth factor beta than does imatinib and dasatinib (IC50 for platelet-derived growth factor 53 nM for nilotinib, 39 nM for imatinib, and 28 nM for dasatinib).

The B. anthracis enzyme was thermally stabilised by the first substrate, pyruvate, to a greater extent than its E. coli counterpart, but has a weaker affinity for pyruvate based on enzyme kinetics and ITC studies.