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For example, a face sample from one person and a fingerprint sample from another person are used as a multi-modal feature set for a virtual subject [30].
In this study, an operator model, which mimics the FDI behavior of a human operator with primary cognitive and executive capabilities, is developed as a virtual subject for supervising a chemical plant system.
A virtual subject was acceptable if simulated behaviors matched specified clinical data characterizing the patient phenotype(s) of interest.
Subsequently, the results of many single-organ measurements are merged into a "virtual" subject for a complete biokinetic model and calculation of absorbed doses.
Each virtual subject's relative contribution to virtual population measurements is weighted by a virtual subject specific prevalence weight; a simple weighting scheme was applied by which each virtual subject was assigned a weight of either 1 or 0 to optimize the fit to clinical data distributions.
A virtual subject trial simulation for "healthy controls," assuming a Gaussian distribution with a variance(s) of 10% for N-methyl D-aspartate-R, 5% for the GABA-R conductance, 15% for D1R activation level, and 10% for the background noise, resulted in an average WM span of 9.18 ± 0.66 s.
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Therefore, a set of multiple modality features that are captured from different subjects are used as a set of features from a single virtual subject.
The subsequent methodology to develop and validate virtual subjects and each virtual population comprised three key steps: 1. Parameter exploration: Variability in key model parameters was explored to generate alternate parameterizations, each of which represents a potential virtual subject.
As a result, each virtual subject is defined by a complete set of unique system-specific parameters.
Blood pressures of all virtual subjects present physiological values with well-balanced distributions (Fig. 2).
In a case study, the evaluation method using the virtual subject is applied for designing an appropriate alarm system in a boiler-plant simulator.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com