The phrase "a very substantial level" is correct and usable in written English.
It can be used to describe a significant degree or amount of something, often in contexts such as research, analysis, or evaluation.
Example: "The study revealed a very substantial level of improvement in the participants' performance after the training program."
Alternatives: "a considerable degree" or "a significant amount".
The NoVo Foundation that Jennifer Buffett leads may not rank among the largest foundations in the U.S., but it is one of the biggest family foundations led by a woman and it gives at a very substantial level: $56.7 million in grants in 2012, placing it in the 100 largest foundations by giving.
There is a very substantial level 1 evidence-base, evaluating pharmacological and cognitive behavioural therapies (CBTs), 19 20 although the latter are very seldom available.
A back pressure applied made it possible to conduct ECAP at a relatively low temperature of 350°C thus leading to a very substantial level of grain refinement.
For example, very substantial levels of differential recall accuracy between patients with bladder and laryngeal cancer would have been required to generate the very large difference in median patient intervals between these two cancers (2 vs 34.5 days, respectively).
However, despite the good fit between model and data for two of the datasets, we find that there could be very substantial levels of unexplained variance and the correlations would remain almost unaffected (Table 1).
In vitro, association of MOF with the MSL1-MSL3 subcomplex results in a very substantial enhancement of the level and substrate specificity of its histone acetyltransferase activity [ 36].
In contrast, even in the presence of these group I mGluR antagonists, Asc-08007-1-1 caused a very substantial depression in peak eIPSC amplitudes, to ∼30% of baseline level.
Cox8b was expressed at a very low level in control iWA, but NE/Rosi treatment led to a very substantial increase in expression (Fig. 4 C ).
A similar requirement in the US and other rich, connected countries, guaranteeing a certain level of outlay for the establishment of remote networks, would produce a very substantial sum of earmarked money.
Simon Albury, chair of the Campaign for Broadcasting Equality, said: "The BBC has announced a very substantial package of initiatives, which will drive significant and welcome improvement in BAME representation at all levels.
Cluster profile 12 is characterized by a very substantial early down-regulation followed by a slight progressive increase in expression that remains below control levels.
