The phrase "a very substantial impact" is correct and usable in written English.
It can be used when discussing the significant effects or consequences of an action, event, or decision.
Example: "The new policy is expected to have a very substantial impact on the company's overall performance."
Alternatives: "a significant effect" or "a considerable influence."
"In the near term, it would have a very substantial impact," he said, emphasizing that in principle, P.G.& E. supports Mrs. Feinstein's efforts to preserve sensitive desert lands.
"Since Alzheimer's strikes late in life, delaying the onset of disease by just a few years could have a very substantial impact," he added.
"Whatever concerns the larger institutions had seemed to have a very substantial impact," said Michael Botwinick, director of the Hudson River Museum in Yonkers, who serves on the board of the Museum Association and said he felt "blindsided" by the Regents' decision.
"I think there's no question that that had a very substantial impact upon the council," Braude said.
Stratum E includes the countries in sub-Saharan Africa where HIV/AIDS has had a very substantial impact.
Some cytogenetic subgroups are doing particularly well and the introduction of differentiation treatment with all-trans retinoic acid or arsenic trioxide in acute promyelocytic leukaemia has made a very substantial impact in this cohort.
Although these developments were only indirectly influenced by Dirac, by way of the mathematical developments that are associated with his formal approach to quantum mechanics, there are other elements of his work that had a more direct and very substantial impact on the development of QFT.
Finally, supporting our earlier analysis, κ C, increased from 0 to 0.498 [0.1766 0.536], p < 10−3) which results in a very substantial behavioral impact, since this sets the asymptotic performance on the easiest contralateral trials to ≈50%.
This paper presents basic evidence about the very substantial impacts of general cognitive skills on individual earnings and on economic growth.
An illustrative numerical example for a three-region, four-sector, three-factor economy clearly demonstrates that increases in resource demand may have minimal, moderate, or very substantial impacts on prices of resource-intensive goods and on scarcity rents, depending on the global abundance and distribution of the resource relative to the volume of demand.
