A: Very small quantities, and we stopped.
However, if we calculate the proportion of coexpressed enzyme-coding gene pairs over all the possible combinations of genes involved, only a very small fraction of combinations (0.2 3.9%) showed coexpression (Additional File 5) indicating the presence of multiple layers of regulation of the metabolic network not restricted to the level of gene expression.
The human expert, limited by experience, knowledge and time, can only try a very small number of conventional combinations.
By considering bi-cliques, we take into account many interrelationships among the alleles and are able to make use of a procedure that only needs to look at each combination a very small number of times, thereby keeping the computational effort manageable despite the large number of combinations.
Pt/SrTiO3/BiMnO3/SrTiO3/Pt and SrRuO3/SrTiO3/BiMnO3/SrTiO3/SrRuO3 capacitors were also reported to show good ferroelectric properties with a remnant polarization of around 9 to 16 μC/cm2 but in combination with a very small saturated magnetic moment, M sat < 1.0 μB/Mn [14].
By chance, in a very small proportion of mutated cells the combination of genes affected will be such that it endows them with survival advantage and preferential retention during prolonged passaging.
The justification for maintaining the species' status as vulnerable is that "There are no direct or immediate threats, but the combination of a very small range and population may have important implications for its chances of long-term survival, and this species consequently qualifies as Vulnerable".
However, estimating amino acid substitution probabilities is not a trivial problem, especially when there are a very small number of observations in specific combinations of environments.
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A very small fraction of CD56dim expressed two KIR combinations without 2DS4 (0.80% to 1.64%).
