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The phrase "a very significant topic" is correct and usable in written English.
You can use it when discussing a subject that holds considerable importance or relevance in a particular context.
Example: "In today's lecture, we will explore a very significant topic that affects our understanding of climate change."
Alternatives: "an extremely important topic" or "a highly relevant topic."
Exact(1)
Decreasing warpage is a very significant topic to improve the quality of injection-molded parts.
Similar(59)
Information integration is a very important topic.
Hyzy: Yeah, it's a very important topic.
Power quality is a very important topic nowadays.
It hit home that this is a very important topic.
"It's a very important topic," Brady said.
Berusch: Education is also a very important topic.
I deeply regret my comments on a very important topic.
So therein lies a very significant problem".
This is a very significant book.
We have lost a very significant amount".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com