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The phrase "a very significant proportion of" is correct and usable in written English.
It can be used when discussing a large part or percentage of a particular group or category in a formal or academic context.
Example: "A very significant proportion of the population supports the new policy, indicating a strong consensus among citizens."
Alternatives: "a large percentage of" or "a considerable amount of".
Exact(14)
Chinese purchases of U.S. bonds in 2005, for example, are estimated to have risen as high as 2percentt of our G.D.P., a very significant proportion of America's foreign borrowing.
They conclude that the pension credit means that "a very significant proportion of people planning to retire in the distant future face an unambiguously reduced financial incentive to save".
Andrew Denman, the president of the Tasmanian special timbers alliance, said his industry welcomed the potential delisting because a "very significant proportion of the specialty timber resource was locked up without any consultation" by the Tasmanian forest agreement and extension of world heritage areas.
Her closest male friends have Nigerian, Egyptian and Greek Cypriot backgrounds, and the student body as a whole has a very significant proportion of students whose families have come from, or still live in the Indian sub-continent and the Far East.
"A very significant proportion of our national wealth is controlled by The Forbes 400," Belew ruled.
"And thankfully in the UK we do have a regulated broadcast sector, which provides for a very significant proportion of trusted news". It was "very difficult" for governments to take action against fake news without undermining free speech, said Mr Hancock, and the best way to tackle it was through fact checking, education, transparency and other methods of "challenge".
Similar(46)
Among those who do come out early, a very significant proportion not only manage, but thrive.
His successor Malcolm Turnbull, has, while an Abbott government minister, given motherhood support to the well-funded Recognise movement (there is no such taxpayer support for the very significant proportion of Indigenous Australians who currently oppose recognition).
Although the majority of patients responds very well, a significant proportion of patients has to withdraw from TNF-α blocking therapy due to inefficacy or adverse events [ 12- 14].
16 The involvement of primary care administrators in health services research, particularly with a focus on safety and improvement appears very limited, with a significant proportion of studies undertaken over a decade ago.
In fact, it is very likely that a significant proportion of the genetic diversity exhibited by extant bacteria might be the result of the acquisition of sequences from more or less distantly related organisms [ 1].
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com