Sentence examples for a very significant problem from inspiring English sources

So therein lies a very significant problem".

"District 6 has a problem, a very significant problem".

Mathematically speaking, "Napoleon Dynamite" is a very significant problem for the Netflix Prize.

"It's a very significant problem," said the attorney general, Richard Cordray.

"This is a very significant problem," said Daniel Smith, president of the American Cancer Society's Cancer Action Network.

NICK PAUMGARTEN: Some of the women I talked to would say this was a very significant problem.

"It's clear that the burden of osteoporosis and fractures is greater in women, and what has happened is that has overshadowed a smaller but very significant problem in men," said Dr. Eric Orwoll, professor of medicine at Oregon Health Sciences University.

Therefore, immune-mediated rejection of genetically altered cells is a general and very significant problem in transplantation studies using cells labeled with any marker gene, and also in gene therapy protocols.

"The sadness is that we still have very significant problem," Dr. Dover said.

And even today, when the L train is operating "perfectly," you already have this very significant problem where if you try to get on at 8 30, 9am, invariably, it's just massively crowded.

All items on the ILC are rated on 5-point Likert scales (items 1-7: 1 = very good, 2 = rather good, 3 = mixed, 4 = rather bad, 5 = very bad; items 8-11: 1 = no problem, 2 = minor problem, 3 = moderate problem, 4 = significant problem, 5 = very significant problem).