The phrase "a very significant increase" is correct and usable in written English.
It can be used when discussing a notable rise in data, statistics, or any measurable quantity.
Example: "The company reported a very significant increase in sales this quarter compared to the last."
Alternatives: "a substantial increase" or "a considerable rise".
That would be a very significant increase.
We have seen a very significant increase in the prison population since 1993 and an almost halving in the rate of crime.
"The time is coming when we're going to see a very significant increase in the retail price of chicken," he said.
"So we are looking in conjunction with our allies and friends in the Afghan government at a very significant increase," he told a security conference there.
Foreign aid programs are a traditional target when Congress looks for cuts, and Republicans noted that State Department operations received a very significant increase in 2010.
"We are at the front end potentially of a very significant increase in the demand for lithium for the emerging electric transportation sector".
Flores said that her campaign had seen "a very, very significant increase in contributions" in an interview on Thursday.
Radiotherapy induced a strong and very significant increase in tumour angiogenesis, which was no longer observed when combined with erlotinib and bevacizumab.
After supplementation, there was a large and very significant increase in the level of CoQ10, and the levels of ATP, NADH, and NADPH all increased very significantly to normal levels.
Furthermore, direct effect of hydroalcoholic extract of C. dactylon rhizomes on isolated rat hearts demonstrated that the extract produce a dose dependent and very significant increase of the contraction force by increasing the left ventricular developed pressure (LVDP) and parallel decrease of end diastolic pressure (LVEDP) and heart rate.
The very significant increase in E.R. visits, it's due to THC content being much higher now".
