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The phrase "a very significant" is correct and usable in written English.
You can use it when referring to something that has a strong, important, or noteworthy effect or implication. For example: "The census revealed a very significant shift in the demographics of the area."
Exact(60)
That's a very significant change.
So therein lies a very significant problem".
This is a very significant book.
We have lost a very significant amount".
It is a very significant breakthrough.
"It's a very significant disablement step".
"This is a very significant ruling.
It's a very significant American piece.
We had a very significant reduction.
It was a very significant shock.
I think it's a very significant step".
More suggestions(25)
a very significant asset
a very significant chunk
a very significant day
a very significant device
a very significant decline
a very significant information
a very significant fraction
a very significant conflict of
a very significant proportion
a very significant dataset
a very significant scale
a very significant topic
a very significant area
a very significant deal
a very significant tool
a very significant historical
a very significant yield
comprise a very significant
displayed a very significant
a very prominent
a very vital
a very noteworthy
a very noticeable
a very remarkable
a very notable
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com