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The phrase "a very sharp effect" is correct and usable in written English.
It can be used to describe a strong or intense impact or impression that something has on a person or situation.
Example: "The artist's use of color created a very sharp effect that captivated the audience."
Alternatives: "a striking effect" or "a profound effect."
Exact(1)
Even smoking addiction has a very sharp effect on DNA methylation pattern among South Asians and Europeans as explained in Section 3.5 with reference to AHRR locus (Elliott et al., 2014; Monick et al., 2012).
Similar(59)
Beyond the image of a slightly quirky professor (exaggerated for effect) was a very sharp political operator.
The result could be a very sharp fall in European GDP, with knock-on effects in the rest of the rich world.
A very sharp cookie.
Cam Newton talks a very sharp game.
So this represents a very sharp reversal.
He had a very sharp breaking ball".
"It's been a very sharp decline.
Use a very sharp knife.
She has a very sharp mind and is very personable.
He was a very sharp dresser, the sharpest.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com