The phrase "a very practical issue" is correct and usable in written English.
You can use it when discussing a matter that is relevant and applicable in real-world situations, often in a problem-solving context.
Example: "The team needs to address a very practical issue regarding the budget allocation for the upcoming project."
Alternatives: "a highly relevant concern" or "a significant practical matter".
Anti-TNFα agents require a short time of administration to reach their effect, and anti-CD20 and abatacept have to compete with this very practical issue that needs to be considered when a choice has to be made to reach a major response.
Far beyond the issue of whether interstellar travel is technologically possible is the very practical issue of where we should go once we have built our first "starship".
Far beyond the issue of whether interstellar travel is technologically possible is the very practical issue of where we should go once we have built our first "starship". The whole idea of interstellar travel was created by fiction writers, but because it has many elements of good science in it, it is a very persuasive idea.
However, one very practical issue in both hospitals is that ObGyn doctors also undertake fulltime work elsewhere in main government birthing facilities in Kathmandu and regularly do not turn up for scheduled clinics.
"There is very clear evidence that on a number of issues; a number of policies, the political leaders are finding their way through very practical issues with practical solutions.
Guardian covered some similar issues regarding Kuhn, but there are other very practical issues such as psychological projection, logical positivism, and motivated reasoning, wishful thinking, that would be productive to reexpose.
"People were unbelievably generous as I was in there trying to pretend how to walk with leg braces and they were there with their leg braces and having to deal with very practical issues," he said.
While working with the Naked team I felt that were some very practical issues with user interface which unfortunately weren't being addressed.
One of the things we'll have to address, quite soon, are the very practical issues like heating and the furniture literally wearing out.
