The phrase "a very powerful advantage" is correct and usable in written English.
You can use it when discussing a significant benefit or edge that one has over others in a particular context.
Example: "Having access to advanced technology provides a very powerful advantage in the competitive market."
Alternatives: "a significant advantage" or "a considerable edge."
"Michael's running in a very tough environment, but he's got one very powerful advantage: he's got you," Mr. Obama said, with Mr. Bennet at his side.
The point of putting computers in orbit isn't actually to do financial things in space per se, but to show that there can be very powerful advantages to running computers in space.
Particularly yeast surface display in combination with high-throughput fluorescence-activated cell sorting has proven successful in the last fifteen years as a very powerful technology that has some advantages over classical generation of monoclonals using the hybridoma technology or bacteriophage-based antibody display and screening.
Social media is now a key component to our existence and it can be a very powerful tool when we take full advantage of it to help better ourselves and create opportunities for ourselves.
The Monte Carlo technique has become a very powerful tool in radiation transport as full advantage is taken of enhanced cross-section data, more powerful computers and statistical techniques, together with better characterisation of neutron and photon source spectra.
Regulation has long been considered as a way to control the mean expression, but it results to be a very powerful and flexible tool for the cell to take advantage of stochasticity by modulating it depending on the context.
The analysis and database system provides a very powerful tool which will enable the Xenopus community to take advantage of a number of technical and experimental advances.
"He is physically a very powerful man and has the ability to offload and break the advantage line.
However, over and above their potential advantage in problem solving, schemes can be a very powerful tool for knowledge organization in an undergraduate curriculum.
The media is a very powerful force, so it will serve you well to use it to your advantage.
