The phrase "a very modest risk" is correct and usable in written English.
It can be used when discussing the level of risk associated with a particular action or decision, indicating that the risk is low or minimal.
Example: "Investing in this startup presents a very modest risk compared to other ventures in the market."
Alternatives: "a slight risk" or "a minimal risk".
Conceptually the framework involves hundreds or even thousands of very modest risk alleles but also some number of rare mutations with a much larger effect on risk for certain individuals.
However, these variants will probably inflict very modest risk increments and physiologic characterization of such loci will be extremely challenging.
Then there are very common SNP genotypes of less utility that confer very modest risk modification for common disorders, such as type 2 diabetes mellitus [ 7].
In a separate finding, Dr. Gammon's study showed that exposure to polycyclic aromatic hydrocarbons, commonly found in pollutants like car exhaust and cigarette smoke, produced a very modest increased risk for breast cancer.
"But such large numbers of people in the country and the world engage in sand contact activities that, even with a very modest relative risk, you could see substantial disease burden".
In addition, most variants seem to confer very modest risks in the order of 1.2 1.6 fold, which are hard to detect given the statistical difficulties described above.
Novel diabetes genes identified by genome-wide association studies, requiring tens of thousands of cases for sufficient statistical power, confer a very modest increase in risk of each risk allele (odds ratios: 1.1 1.2) (108).
Compared with risk with <2 years of NPH use, there was some suggestion of a very modest increase in risk of breast cancer associated with ≥5 years of NPH use (Supplementary Table 4).
The one tentative link was a very modest increase in risk from exposure to polycyclic aromatic hydrocarbons, chemicals that are in grilled food and in cigarette smoke.
