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A very mild decrease in the ratio between the apical and basal domains (A/B) is observed.
However, a very mild decrease in the number of WIPI-1 punctae was observed under non-starved conditions in C2βD1212A/D1212A hepatocytes, compared to WT cells, without any apparent impact on LC3 punctae.
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This is likely a consequence of only a very mild reduction in catalytic activity coupled with a significant decrease in thermostability none of the H334R patients resemble the severe, classic CdLS phenotype.
In HIV-seronegative MSM, randomization to FTC/TDF was associated with a very mild nonprogressive decrease in CrCl that was reversible and managed with routine serum creatinine monitoring.
Even on 12-pNCA, some of the variants have undergone modest increases or very mild decreases in activity.
Indeed, the null mutation in MMP-2 engineered in mice results in a very mild phenotype, manifested mainly by a decrease in bone length [ 9].
The Scl Δ19/Δ19 LSK cells showed a very mild increase in G0 phase and a slight decrease in G1 phase compared with the WT mice; however, both changes fail to reach statistical significance.
We were initially disappointed to find that decreased expression of this factor led only to a very mild immune phenotype, but we later realised that mutant mice lacking Scnhurri-3 display a very striking bone phenotype of extremely elevated bone mass.
"It's a very mild thing.
It has a very mild sexual vibe and some equally mild profanity.
Adventures of a very mild and unexceptional variety ensue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com