Exact(3)
"This is a very major error of judgment," he told a Commons select committee.
A "very major error" occurs when a strain categorized as resistant by the reference method is reported as susceptible by the test.
Three isolates (0.2%) exhibited a very major error, which were susceptible to linezolid (MIC, 2 μg/ml) but nonsusceptible to tedizolid (MIC, 1 μg/ml).
Similar(57)
He added: "Someone somewhere has made a very, very major error".
In this study, the risk for very major error where an isolate would be reported as susceptible despite being resistant or nonsusceptible was rare and was highest for Enterococcus spp, which had a reported very major error rate of only 0.2%.
On the other hand, showed a high frequency of minor errors and 1 very major error for polymyxin B. Etest presented better results for colistin than polymyxin B. Until these results are reproduced with a large number of polymyxins-resistant P. aeruginosa isolates, susceptibility to polymyxins should be confirmed by a reference method.
Very major error (VME) was defined as a difference superior of 2 log2 between the MICs carried out by the two methods, major error (ME) as a difference of 2 log2 and minor error (mE) as a difference of 1 log2.
This study showed 11% of very major error and 30% of major error with Etest and 30% of very major errors with Vitek [ 25].
The polymyxin B resistant isolates were categorized as susceptible by disk diffusion (100%, very major error).
One (1,2%) very major error and 38 (48,7%) minor errors were found comparing polymyxin B Etest with microdilution and 5 (6,4%) minor errors with colistin.
aureus isolates, the very major error rate was 0%, with no isolate showing susceptibility to linezolid while being resistant to tedizolid.
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