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The phrase "a very large preponderance" is correct and usable in written English.
It can be used to describe a significant or overwhelming majority of something in a formal context.
Example: "In the recent survey, there was a very large preponderance of respondents who favored the new policy."
Alternatives: "a significant majority" or "an overwhelming majority".
Exact(1)
The entire list of identified REs, chromosomal coordinates, official gene name, distance from TSS and RE sequence features resulting in the given grade, is available in Additional file 2. The distribution of identified p53 REs grouped based on the functional score, shows a very large preponderance of "grade 1" REs, that are considered as unlikely functional (Fig. 2a).
Similar(59)
A very large one.
"Apple takes a very large cut.
He's a very large fellow.
"Capital raising is a very large challenge".
Johnson had a very large campaign fund.
Only a very large company could compete.
A very large mistake.
A very large box.
in a Very Large Universe.
A: We have a very large facility.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com