The phrase "a very large burden" is correct and usable in written English.
You can use it when describing a significant weight or responsibility that someone has to bear.
Example: "After the sudden loss of her job, she felt a very large burden on her shoulders as she struggled to support her family."
Alternatives: "a heavy load" or "a significant weight."
"Morbidity is a very large burden on families and health systems".
The importance of this measure is that it serves as a needs assessment, marking the existence of a very large burden of ill health to inform health policy in countries and regions the world over.
It assumes that, from a public-health point of view, the important diagnoses are migraine and TTH, but also acknowledges that a very large burden is carried by people with headache on ≥15 days/month.
"It's not a fair situation for those schools, and they bore a very large burden," Cortines said.
In 84.4% of patients, caregivers experienced care as a very large burden.
However, they now account for a very large burden in terms of both mortality and morbidity in low- and middle-income countries (LMICs), although little is known about the impact these diseases have on households in these countries.
This very large burden indicates that continued scale-up of cervical cancer screening and treatment is urgently needed.
The very large burden of cervical disease in HIV positive women reported here necessitates a multi-pronged prevention and control approach, including primary prevention with vaccination, secondary prevention with screening and treatment of precancerous lesions, and treatment of cervical cancers.
Through lost productivity, they generate a very large economic burden that falls upon society [3].
These findings suggest a very large health burden associated with exposure to cadmium at levels experienced by many populations worldwide.
5 Moreover, says Soisungwan Satarug, research advisor at the Centre for Chronic Kidney Disease Research in Brisbane, Australia, "Such data point to a very large disease burden associated with exposure to cadmium at levels experienced by many populations worldwide".
