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No one knows exactly how higher average temperatures will translate into, say, changes in precipitation, but, considering that there are more than six billion people on the planet, it wouldn't take a very large alteration to create very significant problems.
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The reviewers' concerns about data variance in the experimental data also need to be addressed (especially in the 25 day old data) as well as the concern that there is a very large effect with only small alterations in mtDNA degradation.
Right hemisphere lesions have a very large impact and can cause body schema alterations, contralateral neglect, altered postural alignment [ 13], and visuomotor impairment [ 9].
This has prompted us to study the potential role of ALK gene alterations in a very large cohort of CRC in Saudi Arabian patients.
Although genome-wide association studies (GWAS) have demonstrated that common depression is likely to result from alterations in a very large number of genes of small effect (Flint and Kendler, 2014), studies of Wolfram syndrome have identified Wfs1 as a clear example of a gene that can cause MDD in humans (Swift et al., 1990; Crawford et al., 2002; Swift and Swift, 2005).
A very large one.
"Capital raising is a very large challenge".
Johnson had a very large campaign fund.
Only a very large company could compete.
He's a very large fellow.
"Apple takes a very large cut.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com