The phrase "a very high depth" is not commonly used in written English and may sound awkward.
It can be used in contexts discussing measurements or levels, particularly in fields like science or engineering, but it is better to use more precise language.
Example: "The ocean has a very high depth in certain areas, making it difficult for divers to explore."
Alternatives: "a significant depth" or "a considerable depth."
He had used a very low camera angle, at thirty degrees from the horizontal, while setting the tilt to the maximum in order to obtain a very high depth of field.
Luo et al. [ 5] fingerprinted BAC clones which were then assembled into contigs, while Jia et al. [ 21] used a very high depth of short sequence reads to develop sequence contigs/scaffolds.
The confocal channel in the OCT-Ophthalmoscope provides a fundoscopic image with a high transversal resolution which has a pixel-to-pixel correspondence with the OCT channel that possesses a very high depth resolution [ 10].
Our first approach is more costly and involves long-PCR followed by 454 sequencing of individual mtDNAs and generates high quality sequence data, with a very high depth of coverage per nucleotide (up to ~6000×; [ 22]).
The massively parallel and high-throughput nature of NGS platforms, combined with the relatively short genome of an RNA virus, enables the analysis of viral samples (which can contain billions of virions) to a very high depth.
Based on this, we analyzed the presence of mutations in 800 900 bp downstream of the transcriptional start site of two highly transcribed genes in pancreas, Elastase1 (Eland and Elastase2 (Ela2a), by next-generation sequencing, which allows large number of mutations to be analyzed at a very high depth (Perez-Duran et al, 2012).
In this study, we sequenced regions of the 16S rRNA gene at very high depth for a small number of samples (four), resulting in a majority of the estimated GIT microbial diversity being captured.
With very high depth coverage, this score could be used as an indicator of the allele frequency difference between lines.
It uses either one marker (sequenced at very high depth)[ 20] or many (generally randomly amplified)[ 21] to analyze phylotypes and/or functional categories[ 22].
Using our Agilent SureSelect data we picked 10 regions with very high depth (Additional file10: Table S10) and examined them against the pseudo gene lists from Yale and UCSC (http://www.pseugenes.com).
Furthermore, ustacks collapsed over 6000 repetitive SbfI RAD loci in the stickleback genome into a smaller number of loci with very high depths of coverage, as indicated by the long right tail of the distribution that stretches far beyond the truncated display in the figure.
