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The phrase "a very first indication of" is correct and usable in written English.
It can be used when you want to emphasize the initial sign or signal of something occurring or being present.
Example: "The study provided a very first indication of the potential benefits of the new treatment."
Alternatives: "an initial sign of" or "a preliminary indication of".
Exact(1)
The following topics were covered: (i) In vitro tests may give only a very first indication of possible toxicity as in the actual methods interactions at systemic level are mainly neglected; (ii) the science-driven and the regulation-driven approaches do not really fit for decisive strategies whether or not a nanoparticle should be further developed and may receive a kind of "safety label".
Similar(59)
The box: this is the very first indication of a not-so-authentic DS game.
The GRE and TOEFL examinations are a first indication of English proficiency.
He now says it was a "first indication" of the deforestation increase.
This is a first indication of the production technology of eighteenth century glass glitter.
Such results provide a first indication of discriminant validity of the constructs.
"In Westport, the people are very wealthy, and at the first indication of anything, they'll threaten or file a lawsuit".
"This is the first indication of very high-energy neutrinos coming from outside our solar system.
A "septal actomyosin tangle" is the first indication of impending septation.
"This could be the first indication of a bomb.
It was the first indication of a possible motive in the case.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com