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Discover LudwigThe phrase "a very different principle" is correct and usable in written English.
It can be used when comparing or contrasting principles, ideas, or concepts to emphasize the distinction between them.
Example: "While both theories aim to explain human behavior, they are based on a very different principle regarding motivation."
Alternatives: "a significantly different concept" or "a markedly different idea."
Exact(1)
It's a hopeful opportunity to make a vaccine by a very different principle than what we've seen before".
Similar(59)
Assessment of different technologies is difficult as they often involve very different principle of operation, detector size, resolution and illumination.
The Supreme Court is on the verge of replacing the principle of strict separation with a very different constitutional principle that demands equal treatment for religion.
But the Mental Capacity Act (2007) is organised around a very different legal principle: it says that if someone passes a legal test of their capacity to make a decision, then they cannot be treated without their consent – even if they suffer from a major mental disorder.
Insulin detemir has a very different protraction principle.
At present computers and brains work according to very different principles, but we should expect this difference to narrow.
It should be directed at reforming a broken financial system so it works again, if on very different principles.
"The private sector is built on very different principles.
The private sector, by contrast, is built on very different principles.
On the contrary, government and business are built on very different principles.
Follis began his career in the Marines, and the Marines operate by very different principles from those of the D.E.A.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com