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The phrase "a very different position" is correct and usable in written English.
You can use it to describe a situation or stance that significantly contrasts with another.
Example: "After the recent developments, she found herself in a very different position than she had anticipated."
Alternatives: "a significantly different stance" or "a markedly different situation".
Exact(57)
This time we start from a very different position.
The eurozone, however, starts from a very different position.
Phoebe has a very different position on these things.
Mobile operators, however, are in a very different position.
In reality they may find that they reach middle age in a very different position.
This puts Labour in a very different position from the Conservatives in 1990.
Patients who were legally detained were in a very different position.
They are in a very different position than the destitute Somali farmers.
They are in a very different position from the destitute Somali farmers.
Similar(2)
The 601 sequence produced a very different positioning pattern in comparison to any site in the hFIX-Parent vector.
In contrast to these publications, a previous model put forth by Colombini and co-workers, based on biochemical and biophysical data, proposed that S192, an analogous residue in VDAC from the organism Neurospora crassa, is positioned at a very different location in a loop outside the path of ion flow and not in a region spanning the membrane.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com