The phrase "a very different overall" is not correct as it stands and lacks clarity in written English.
It can be used when comparing two or more things, but it needs additional context to convey a complete thought.
Example: "The results of the new study present a very different overall perspective on the issue than previous research."
Alternatives: "a significantly different overall" or "a markedly different overall".
Another recent poll also documented skyrocketing approval ratings for Barak, but showed a very different overall picture, with rightwing parties still holding a substantial lead over the left.
Although each of these proteins has a very different overall fold, in every case the diiron active site is situated within a four-helix bundle.
While the public has an increasingly negative view of Ms. Palin, with nearly half holding an unfavorable view - since April, her favorable rating is down 9 percentage points - Fox News viewers have a very different overall view.
Hybrids of these two species of Xenopus then appear to follow a very different overall pattern of misexpression compared to hybrids in other organisms.
Each of these two clades contains a transcript that together are the two most highly expressed putative toxin transcripts in the venom gland library of G. dibranchiata, but apart from their shared ShKT domains they have a very different overall organization.
A review of the weather data from both years (despite very different overall weather patterns) showed wet conditions at silking conducive to this type of infection.
They have very different overall architecture but share the separation distance between carbohydrate-binding sites.
In addition, male patients and female patients in the heterogeneous group had very different overall age of onset profiles.
Finally, two studies monitored the emergence of multidrug resistance bacteria with very different overall rates.
Thus, despite the very different overall folds of NaD1 and the other phosphoinositide binding domains, key structural features that govern how they recognize phosphoinositides are generally conserved.
