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As de Blasio cruised to an easy victory, his endorsement of Squadron's bill signalled that the new mayor would have a very different orientation toward philanthropy than his predecessor, who famously practiced "government by private checkbook," tapping his own fortune to subsidize various initiatives underfunded by the city or the state.
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The debate was "orienting" because it exposed the very different orientations of the two — one toward tough-mindedness and resolve, the other toward transparency and dialogue; the one toward the peril that we face, the other toward opportunities we must explore.
Loop 4, which encompasses the β-hairpin present in both toxins, also aligns well except for the four-residue insertion in ω-HXTX-Hv1a, which increases the size of the hairpin loop at the tip of Loop 4. The major structural differences between the two toxins are the very different orientations of loops 2 and 3.
Previous studies have examined characteristics of mentally ill patients with versus without involvements with the legal system [ 26] or examined psychopathology in prison populations, but such studies are of a very different nature and orientation.
In the contrast of orientation versus interpolation (Figure 4C & 4D), a very different pattern emerged.
"A very different city".
A very different proposition.
A very different experience.
A very different picture emerged.
It is a very different party.
But women have a very different story.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com