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The phrase "a very different hypothesis" is correct and usable in written English.
It can be used when discussing or comparing hypotheses that are distinct from one another in a significant way.
Example: "After reviewing the data, we concluded that our findings support a very different hypothesis than previously suggested."
Alternatives: "a significantly different hypothesis" or "a markedly different hypothesis".
Exact(1)
In 1993, a very different hypothesis about the function of menstruation captured popular media attention.
Similar(59)
Of specific concern to substantive researchers, the Bayesian paradigm offers a very different view of hypothesis testing (e.g., Kaplan & Depaoli, 2012, 2013; Walker, Gustafson, & Frimer, 2007; Zhang, Hamagami, Wang, Grimm, & Nesselroade, 2007).
But Gold proposed replacing the question with a very different one: Which tentative hypothesis is the one to pick, given the data provided so far, assuming a finite number of wrong guesses can be forgiven?
Intriguingly, while the other genes in the tandem array share near-identical 3'UTR sequences, Tb927.4.5240 has a very different 3'UTR, consistent with the hypothesis that the 3'UTR contains regulatory elements that determine differential gene expression[ 29].
Statistical significance testing was initially designed for testing hypotheses in a very different area, and hence the question must be asked: does it transfer into empirical software engineering research?
"A very different city".
A very different proposition.
A very different experience.
I have a very different perspective.
"I felt a very different presence".
It was a very different energy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com