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The phrase "a very different genus" is correct and usable in written English.
It can be used when discussing classifications or categories that are notably distinct from one another, particularly in scientific or biological contexts.
Example: "While both species are mammals, they belong to a very different genus, highlighting their evolutionary divergence."
Alternatives: "a significantly different category" or "a markedly different type".
Exact(1)
But dengue isn't the biggest mosquito-borne killer; that's malaria, which is responsible for the deaths of more than half a million people annually and is transmitted by Anopheles mosquitoes, a very different genus.
Similar(59)
A very different experience.
"A very different city".
A very different proposition.
But this was a very different scenario.
I got a very different answer.
"It's a very different electorate".
South Africa were a very different proposition.
So it's a very different thing.
I have a very different perspective.
"I felt a very different presence".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com