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The phrase "a vastly negative effect" is correct and usable in written English.
It can be used to describe a significant or extensive detrimental impact of something.
Example: "The new policy has had a vastly negative effect on employee morale and productivity."
Alternatives: "a profoundly negative impact" or "a significantly adverse effect".
Exact(1)
We don't think this freedom for developers would constitute an improvement to the current system, but it would almost certainly have a vastly negative effect on living standards at the lower end of the market.
Similar(59)
It's completely ineffective, which means that we must stop it immediately, or else this ineffectual policy will somehow have vastly negative effects on something or other (not clear what).
So once again, we're faced with a situation in which a study that tenuously claims a negative effect of playing video games is vastly overhyped, both in the press release and the subsequent media coverage.
Moving to a larger class had a negative effect.
A cliff edge could have a sharp, negative effect.
But over time this has had a subtle, negative effect.
THE EFFECT ON HIS FAMILY It had a very negative effect on my family.
"But it's a jobs program that has a direct negative effect on people's lives.
These and other disheartening factors have a compounding, negative effect on a woman's superannuation savings.
In Angelo's case, the pills had a predominantly negative effect.
"Even if there was no arrest," it said, "there is a lasting, negative effect".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com