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The phrase "a vast difference in" is correct and usable in written English.
It can be used to highlight a significant disparity or distinction between two or more things.
Example: "There is a vast difference in the quality of service between the two restaurants."
Alternatives: "a significant difference in" or "a considerable difference in".
Exact(33)
The epidemiology of polyarticular JIA varies worldwide with a vast difference in reported cases between different global regions as well as within individual countries.
Although ISIS does not indiscriminately claim it's behind different attacks, there can be a vast difference in how involved the group's leaders are in orchestrating them. .
CSPnl can exhibit distinct failure modes under different test board and/or CSPnl designs, resulting in a vast difference in drop test lifetimes.
Andy Robinson's side will have to counter a vast difference in experience.
These are all details, but they added up to a vast difference in impact.
Yet there's a vast difference in the evidence for safety and effectiveness that manufacturers must have to sell them".
Similar(27)
I realize that there is a vast difference between living in Washington, D.C. and living in New Delhi.
BEIJING — Results of a wide-ranging survey of Chinese family wealth and living habits released this week by Peking University show a wide gap in income between the nation's top earners and those at the bottom, and a vast difference between earners in top-tier coastal cities and those in interior provinces.
There is a vast difference between gathering in such numbers to protest something deemed politically unacceptable and burning cars after the loss of a hockey game.
But there is a vast difference between a situation in which the Bank is fully holding its own and one in which it was losing heavily every week.
"Plainly there is a vast difference," Justice John Paul Stevens wrote in 1989, "between the public records that might be found after a diligent search of courthouse files, county archives and local police stations throughout the country and a computerized summary located in a single clearinghouse of information".
More suggestions(16)
a tremendous difference in
a considerable difference in
a gigantic difference in
a significant difference in
a great difference in
a widespread difference in
a wide difference in
a broad difference in
a massive difference in
a large scale difference in
a broader difference in
a vast amount in
a vast estate in
a vast shift in
a vast change in
a vast business in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com