Sentence examples for a variation in the sequence from inspiring English sources

Additionally, as mentioned before, a variation in the sequence and/or the arrangement of the regulatory elements is found to affect the splicing pattern, hence we expect that an arrangement of regulatory elements that is not conserved between orthologous exons must be related to a lack of conservation of the exonic structure of the transcripts including that exon.

The ACMG category (3) and the IARC 'uncertain' classification both indicate a VUS result, meaning that while the analysis detected a variation in the sequence, the causal relationship between this particular variation and hereditary risk of disease is unclear (Table  1).> -wrap-foot> aCategories have been summarized for brevity.

generates a variation in the sequences.

A variation in the DNA sequence that occurs in a population with a frequency of 1 % or higher is termed a polymorphism [ 26].

CNV is a variation in the DNA sequence and can affect the expression of nearby and distal genes, causing phenotypic differences.

For the SNPs found in coding regions, only a subset of the polymorphism will result in a variation in the amino acid sequence of the encoded protein (i.e. the non-synonymous substitutions).

Because samples were pooled by equal mass, a variation in the number of sequences recovered from each sample likely reflected slight biases in PCR efficiency among the primer barcodes.

Both PTPD1 and HDPTP have a variation in the highly conserved WPD loop sequence where a glutamate replaces the conserved aspartate residue.

A polymorphism is a common variation in the sequence of DNA among individuals (>1% of the population).

There was a wide variation in the sequence identity to the closest GenBank match, ranging from 79 to 100%% identity.

Technical artifacts excluded (e.g. hybridization differences) (12); cis-regulatory effects can usually be mapped with high statistical significance and could be explained in most cases by a variation in DNA sequence in the regulatory regions of the target gene (13).