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However, the experienced of those suffering from LBP, or 'backnicks' – a turn of phrase coined by Borkan et al. emphasising a perceived variant category of social role/expectation–[ 34] may materially differ from the experience of people with chronic musculoskeletal pain because of unique societal prejudice towards LBP sufferers.
Association between the male:female carrier ratio and de novo variant category.
For the rounded environment, two speakers showed the same combinations across the two trials ([L] and [L]/[D]), while four speakers adopted combinations that only differed by one variant category ([R]/[L] vs. [Z]/[R]/[L]; [R]/[L]/[D] vs. [Z]/[L]/[D]; [Z]/[L] vs. [Z]/[L]/[D]).
Gene-sets with nominally significant burden for at least one variant category (P < 0.10 for LoF and splicing regulatory, and P < 0.05 for missense variants) were then tested for the joint burden of the three variant categories with a multivariate, two-sample Hotelling's T-Square test (Hotelling 1931).
Variant analysis is at present imperfect and the variant category reported does not imply 100% certainty.
First, we tested "neurofunctional" gene-sets (i.e., affecting brain-related functions most likely to be important to schizophrenia expression), separating each variant category (LoF, missense, splicing regulatory).
By default VASP reports are sorted progressively on four measures: variant category (novel, rare, no frequency and common), the number of variant affected samples (in descending order), the number of unaffected variant samples and lastly the variant population frequency.
The "gene variant" category included all the sequences that overlapped known exons but also aligned to unannotated or intronic regions that may indicate immature transcripts, transcript variants or different gene structures.
These changes in variant categories have had an impact on 756 patient reports.
The effect of gender was robust in realizing all five major variant categories of /dz/, but in a manner more complicated than expected.
To investigate whether the effect of the two main MC1R variant categories on melanoma susceptibility was independent of pigmentation traits, we conducted a multivariate analysis including the main clinical melanoma risk factors using logistic regression (Tables 3(a) and 3(b)).
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