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NRs share a modular structure, which includes highly conserved DNA- and ligand-binding domains (DBDs, LBDs) spaced by a variable hinge region [1], [2].
A variable hinge region connects both domains.
All HP1 family members share a similar structure: an amino-terminal chromodomain (CD), a variable hinge region and a carboxy-terminal chromoshadow domain (CSD) [ 8].
It has been well established that the PPARs can be divided into five distinct functional regions, which include DBD (DNA-binding domain), LBD (ligand-binding domain), AF1 (activation function 1), AF2 (activation function 2), and a variable hinge region.
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The DBD links-up to the LBD by an extremely variable hinge region that contains the nuclear localization sequence and provides flexibility to NRs (1 4).
All these regions except the variable hinge region are highly conserved among PPAR members and are responsible for keeping their functions [ 3].
In addition, a Bayesian probability network (BPN) is developed which entails modeling random variables, the likely failure modes and a variable for the plastic hinge formation criteria for incremental dynamic analyses (IDA).
As shown, there are four major structural features found in these receptors: A signal peptide followed by a variable number of LRRs, a "hinge" region with conserved motifs at each end, and the 7TM region.
A parametric analysis is then carried out to obtain the bending rules of hybrid intelligent hinge system, based on which the hybrid intelligent hinge system with a variable range of recovery moment can be designed.
The comb jelly and sponge LGRs have LRR domains with a variable number of repeats (7 26) and hinge domains that can be quite extended or nonexistent.
Although efforts were made to delineate the relationship between timing of outcomes and 5-HT3 RA use, the temporal relationship between these two variables hinged on when providers submitted related claims.
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