The first validated relationship is a positive connection between the ribonucleotide reductase RRM2 and the DNA topoisomerase TOP2A, two genes that map to the DNA replication pathway.
A "parametric" or "top down" estimate uses validated relationships among cost, schedule, and measurable attributes of systems, hardware, and software.
The STRING [ 32, 33] network mapping tool was also employed to identify coexpressing or experimentally validated relationships among the candidate genes.
This work presented development of a validated quantitative structure-property relationship (QSPR) model obtained from k-fold double cross-validation technique in order to find out the key structural information required to enhance the sweet potency of the molecules.
Our main objectives were to confirm results of earlier studies using clinically confirmed TB cases and to investigate possible confounding of the relationship using a validated questionnaire and exposure assessment in the kitchens of a subset of participants' houses.
17 20 As fragility fractures can be associated with both skeletal and non-skeletal factors, we used the SF-36 Questionnaire, a validated instrument for evaluating the relationship between physical activity and osteoporosis and/or fragility fractures, in this study.
Objective: The aim in the present study was to investigate the prevalence of sleep disturbances in children with migraine and TTH using a validated sleep screening instrument, and the relationship between sleep disturbances and headache features (eg, frequency, duration, intensity).
Measuring severity of dependence directly with a validated instrument probably helped us to detect this relationship.
This procedure allowed quick and efficient generation of biologically meaningful and literature-validated relationships between the genes retrieved.
An AD is one of the pillars of a validated model according to the OECD principles for quantitative structure activity relationship (QSAR) models [6].
Using a validated and reliable survey, Saiki et al. (2012) examined the relationship between food and stress.
