SSc was therefore chosen as a paradigm to investigate the use of corticosteroid therapy and immunosuppressive therapy in a rare, severe disease with limited evidence for its efficacy and an absence of validated recommendations or guidelines.
Combined, our findings provide empirically validated recommendations on the design and implementation of ubiquitous crowdsourcing.
This was conducted in accordance with validated recommendations [ 19].
3 Due to the paucity of data, no validated recommendations in these situations are available.
Our systematic review shows that most of the perceptions and practices of practitioners are not supported by scientifically validated recommendations from research.
If I were advising a policymaker, I would feel more comfortable basing my recommendations on a validated structural model rather than on an impact evaluation that is not informative on impact drivers, or on a structural model based on assumptions that have no or scant justification in the data.
The recommendation to use a validated delirium tool is reinforced by the fact that the ICU team is used to conducting clinical research and quality improvement projects in the area of agitation, sedation and analgesia [45 47].
6 Current recommendations for laboratory workers with exposure to B. pseudomallei suggest that baseline and post-exposure serology should be used for accurate interpretation of seropositivity after a potential exposure event, but the recommendations caution that a validated assay such as the IHA should be used.
d) Clinical blood pressure (OMROM M-7): three measurements of systolic blood pressure (SBP) and diastolic blood pressure (DBP) will be made, calculating the mean of the last two readings, and using a validated sphygmomanometer (OMRON M7), following the recommendations of the European Society of Hypertension.
The use of a validated sedation assessment scale was also specifically recommended (grade B recommendation).
Recommendations For detection of serum TgAbs, a validated quantitative immunoassay standardised against the First International Reference Preparation 65/93 is recommended.
