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Main outcome measures Rates of antidepressant dispensings, psychotropic drug poisonings (a validated proxy for suicide attempts), and completed suicides.
Nevertheless, PDC remains a validated proxy for true adherence and represents one of the most commonly used approaches [ 18– 20].
The main dependent variable was the concentration of total blood mercury (TBHg), a validated proxy measure for recent MeHg intake [ 33, 34].
Briefly, as a validated proxy for PAH DNA adducts, BaP DNA adducts in extracted white-blood-cell DNA were analyzed using high-performance liquid chromatography/fluorescence method for BaP tetraols (Alexandrov et al. 1992; Rojas et al. 1994), modified as described (Perera et al. 2007).
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Of course, these results are not necessarily a legitimate or validated proxy for an anergic immune system, but due to the absence of a clinically established and relevant indicator for immune suppression in daily practices, the data might serve as further hints for this hypothesis, which has been much more clearly described in models of experimental sepsis.
To the best of our knowledge, this is the first study comparing the effect of the recently proposed ADA criteria of elevated A1C (5.7–6.4%) with both FPG and 2-h postchallenge glucose on subclinical atherosclerosis, a well-validated proxy of cardiovascular disease.
The availability of a validated parent proxy-report measure in FM provides the opportunity to estimate child HRQOL when the child is either unable or unwilling to complete the HRQOL measure.
The availability of a validated parent proxy-report measure in pediatric population health provides the opportunity to estimate child HRQOL when the child is either unable or unwilling to complete the HRQOL measure, or as proxy information when young child self-report scale reliabilities do not achieve the 0.70 standard.
Cognitive status was determined using the Dementia Screening Scale (DSS) [ 26], a validated eight-question proxy-rating screening tool for use by nursing staff.
In line with this, while we examined both an individual-level measure of SES (educational attainment as a proxy) and a validated area-level composite index that included education, occupation, income and crowding at the smallest area-level available, other aspects that contribute to SES such as discrimination and rank, may not be captured by either measure.
However, the use of administrative data to study the clinical effectiveness of medications for inflammatory arthritis, such as rheumatoid arthritis (RA), has been limited by the lack of a validated algorithm to serve as a proxy for clinical improvement in RA disease activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com