These sporadic mutations hardly explain the universal decrease in the expression of Axin in many cases of cancer [ 12].
Upon light-to-dark transition, dramatic and universal decreases in transcription level of the majority of the genes in the genome of the unicellular cyanobacterium, Synechococcus elongatus PCC 7942 are observed.
Second, incorporation of several conserved targets in a universal vaccine may decrease the likelihood and rate of emergence of escape mutants and increase the strength of protection.
Menzerath's insight suggested the existence of a universal tendency of parts to decrease their size when systems enlarge.
It has recently been suggested that body size decrease is a universal response to climate change (e.g. Gardner et al. 2011; e.g. Sheridan and Bickford 2011).
However, such a co-intervention would be expected to have a universal effect, and antibiotic use decreased only amongst the bronchiolitis patients.
In the same way that there is no a universal dosage of sodium nitroprussiate to decrease systemic vascular resistance, it would be difficult to propose a universal level of PEEP for all patients with respiratory failure.
Following the introduction of rotavirus vaccination in the US and a universal mass vaccination program in Austria, decreases in hospitalisations for rotavirus and gastroenteritis with no specified cause were observed among unvaccinated children and young adults (aged <24 years) [66, 67].
The results from the evaluation suggest that inequalities can decrease in response to a universal exemption (Fig. 1).
A universal ARV treatment program has rapidly scaled up and resulted in a decrease in the number of deaths from HIV/AIDS after 2003; however, this decline remains unstable.
Although decreased glucose uptake after injury seems to be a universal response, the underlying mechanism remains unknown.
