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For example, two days of intense debate among 25 bioinformatics researchers produced the following definition: "A gene is: 'a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions'".
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Dawkins' (1976) concepts of the meme and extended phenotype provided a name for a unit of cultural inheritance and at least a partial justification for viewing cultural evolution within a biological framework.
Today, such difficulties have exploded, and they have come to challenge the very idea of a discrete and particulate unit of inheritance.
As a fundamental form of genetic variation and the unit of inheritance, a haplotype may affect phenotypes either directly through influencing promoter activity and protein structure (Drysdale et al. 2000; Joosten et al. 2001) or indirectly through tagging nearby untyped causal variants (Clark 2004; Servin and Stephens 2007).
Consideration of nanoparticle inheritance leads to an important question what is the unit of inheritance?
The smallest possible unit of inheritance is a single mtDNA molecule; some studies have hypothesised that the unit of inheritance consists of groups of mtDNA molecules.
Prevailing theory suggests that mtDNA is maternally inherited, with mtDNA nucleoids the unit of inheritance.
The scientists took faecal samples from 124 Europeans and analysed the DNA they contained, using powerful "gene machines" that could quickly decipher the order of the genetic "letters" running along the length of each DNA molecule, the unit of inheritance.
As Darwin would have loved to have known, genes made of DNA are the basic unit of inheritance.
Surveying results from the biology of microbes and metagenomics, Dupré argues that phenomena of horizontal or lateral gene transfer as well as fundamental symbiotic dependencies between microbes and their embedding multicellular communities present a severe challenge to the traditional notion of the monogenomic biological individual (organism) as the focal unit of inheritance and selection.
This development has not only been promoted as a revolution in molecular biology, defining the post-genomic era (see Meloni and Testa 2014 for a discussion of the sociology of hype and expectation in this respect), but has led to yet another change in the concept of the gene, in so far as it can no longer be seen as the only unit of inheritance and selection and the primary cause in development.
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