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The phrase "a unique sign" is correct and usable in written English.
It can be used to describe a sign that is one-of-a-kind or distinct in some way, often in contexts related to branding, symbolism, or communication.
Example: "The artist created a unique sign for the gallery that captured the essence of her work."
Alternatives: "an exclusive sign" or "a distinctive sign".
Exact(3)
One of the newest, a PET scan, shows plaque in the brain -- a unique sign of Alzheimer's brain pathology.
Other changes associated with ITB found in our study included ascites (n = 3), mesenteric thickening and hypervascularity (comb sign; n = 2), suggesting that the comb sign is not a unique sign of Crohn's disease as mentioned in previous literature [ 28].
As a consequence, the derivatives of the concentration variables have a unique sign pattern: for all x, y ∈ D, it holds that sign(F i (x)) = sign(F i (y)) ⊆ {−1, 0, 1}, where sign(A) ≜ {sign(a)∣ a∈ A} denotes the signs of the elements in A (Batt et al., 2008).
Similar(57)
Kata kolok, known as "the talk of the deaf," is a unique, rural sign language, independent of international or Indonesian sign language.
For a unique getaway, sign up for the four-day cattle drive on the Blackfeet Indian Reservation.
Each animal has its own unique sign to interpret.
Just as medical researchers have to study a virus before they can create a vaccine, antivirus makers must capture a computer virus, take it apart and identify its "signature" — unique signs in its code — before they can write a program that removes it.
With the advent of computer graphics and printed vinyl, store owners also found they had a lot more latitude to create their own unique signs, without having to share their marquee with other brands.
By cross-referencing the animals' genomes, the researchers were able to focus on seventy giraffe genes that show unique signs of adaptation.
The unique sign-switching envelope of (operatorname {PAL}_{k}(x)) is determined by the sign-switching of the constituent Rademacher functions.
WA3 is offering replicas of these unique signs to discourage theft, and the proceeds raise funds for future sign maintenance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com