In silico target prediction revealed that each seed binds a unique set of target genes, and only 13.1 and 9.4%% of the target genes are regulated by the two highly expressed seeds of miR-146b-5p miR-146b-5p miR-146b-5ptively (Fig. 2).
Apart from possessing antiglycating activity, RIF activates the FOXO transcription factor DAF-16, possibly through JNK pathway, to modulate transcription of a unique set of target genes, those that are not controlled by the Insulin-IGF-1 signaling pathway.
NKX2-5 mutants, including those with a crippled homeodomain, bound hundreds of targets including NKX2-5 wild type targets and a unique set of "off-targets", and retained partial functionality.
It is well known that CAR-modified T cells face a unique set of challenges during the targeting of solid tumors (Gilham et al., 2012).
Myriads of file formats, programming languages, platforms, operating systems, programming paradigms, distribution models, and access methods have been employed in hundreds of largely-independent projects, each vying for widespread adoption and often offering a unique set of functionalities and features to target a specific subdomain or application of chemistry.
"It is a unique set of assets reaching a huge target market: the Hispanic audience," said David Joyce, a managing director and media analyst at International Strategy & Investment.
These results suggested that PMPC-b-PDPA/siRNA complex nanoparticles targeting a unique set of oncogenes could be developed into a new therapeutic approach for NSCLC treatment.
As mentioned earlier, each Ca2+-CaM complex (with variable numbers of Ca2+ ions bound) may have a unique set of K1 and K2 constants for a target protein or peptide.
SomaticSniper (Larson et al., 2012) has no minimum depth requirements and thus is liable to return a unique set of candidates at the low depths that surround target regions in an exome capture assay.
But each NGO used a unique set of activities to achieve its goals and reach the local target population.
