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Although our study has found a unique progression in MT thickness changes and provided a promising technique for clinical assessment of LHON, further study is warranted.
Remarkably, phylogenetic analysis suggests that the shift from unicellular to multicellular organisms with differentiated cells was not a unique progression in the evolution of life, but it was, in fact, a frequent event [ 1- 4].
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DCM in Doberman Pinschers is inherited and typically shows a unique disease progression with a late onset [ 1, 4- 8].
Could you discuss this? —Susanna, Liberia; Cheryl, Westchester City. A. Although we think of Alzheimer's as a single homogenous disease, it's more accurate to think of it as a constellation of closely related diseases with each genetic defect resulting in a unique pattern of progression depending on brain areas affected.
This has enabled the collection of a unique summer-thaw-progression data set in two Circumpolar Active Layer Monitoring (CALM) network sites since 1996.
Ankylosing spondylitis (AS) displays a unique pathology in its progression from an initial inflammatory phase to an osteoproliferative/ankylosing phase, which can result in joint fusion [ 1].
These data suggest that EndMT is an important mechanism for CAF recruitment to the tumour stroma and that these CAFs may have a unique role in tumour progression.
In summary, the findings suggest that ASP may play a unique role in the progression of adverse cardiovascular events, independent of insulin.
While a single measurement of the level of either of these metabolites does not indicate a unique point in the progression of the disease, it is a helpful indicator of the level of inflammation.
Therefore, fibroblastic and myofibroblastic cells generated from epithelial cells adjacent to tumours (cancer-associated epithelial cells) by EMT and EMyoT, respectively, might have a unique role in cancer progression that is distinct from those of ordinary fibroblasts.
Intriguingly, mounting evidence indicated that breast cancers with BRCA1 mutation were more likely to exhibit triple-negative phenotype compared with the BRCA1 noncarriers [ 18, 20, 40– 49] 49], which showed that BRCA1 could play a unique role in the progression of TNBCs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com