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The phrase "a unique problem when" is correct and usable in written English.
It can be used to introduce a specific situation or context in which a particular problem arises.
Example: "There is a unique problem when trying to balance work and personal life in a remote working environment."
Alternatives: "a distinct issue when" or "a specific challenge when".
Exact(1)
Every specimen is a unique problem when it comes to preparation, and the way this one is preserved suggests it will require a particularly delicate touch.
Similar(59)
However, pinnipeds present unique problems when using chemical immobilization agents because they have evolved specific adaptations in their respiratory, cardiovascular and thermoregulatory systems enabling them to dive for extended periods.
In the second case, a unique problem to CPOE occurred when a loading dose of phenytoin was not administered because a stage of prescription activation was not correctly carried out; the computer-generated order for the nurse to administer the drug was not triggered due to poor prescribing practice, leading to the dose being omitted.
It's not a unique problem and comes with the territory when you're a rookie in the NHL.
Or they may get paint-by-the-numbers advice when they really need help with a unique problem.
This presented a unique problem.
It was hardly a unique problem, though.
That flexibility creates a unique problem.
"It is treated as a unique problem, and you come up with unique situations.
"This was a unique problem with this fund.
Electrical disorders present a unique problem of classification.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com