The present findings met with the findings of another study conducted on MS patients that demonstrated that IL-17 F CT genotype and C allele may be associated with a susceptibility to MS in Egyptian population by a gender-dependent mechanism that contributes to unique predisposition in females.
"The literature suggests that some patients have a unique genetic predisposition that increases their risk of toxicity," he said.
The studies by Cho et al. [ 52] and Lauenborg et al. [ 51] suggest that GDM does not have a unique genetic predisposition and, at a minimum, that there is some overlap in genetic susceptibility to GDM and T2DM.
41 Whether this is stronger in those whose mother had severe HTN during pregnancy requires investigation as the impact of maternal hypertensive pregnancy on offspring risk could be mediated through either a unique familial predisposition or the in utero environment.
Only a small minority of all individuals infected with H. capsulatum go on to develop PHFM, so it has long been suspected that these patients have some unique predisposition.
The model posits that healthcare treatment or use is affected by: (1) each individual's unique predisposition for using services (predisposing factors), (2) the means available to each individual for obtaining services (enabling factors), and (3) each individual's level of need (need factors).
This specific, elevated blood pressure profile, particularly in offspring of more complicated pregnancies, may represent a unique underlying biological predisposition to HTN.
However, a unique combination of predisposing factors — including genetic predisposition, geographic distribution, female gender bias, chronic inflammation and congenital developmental abnormalities — makes this type of cancer unique and offers potential for understanding cancer pathogenesis in general.
Loss of matK from the plastid genome of Cuscuta is only possible due to a unique combination of tRNA loss related to heterotrophy and a predisposition for plastid intron loss that is otherwise unknown in land plants.
Each individual seems to carry a unique combination of adverse and protective variants, which may represent a personal "genomic fingerprint" of disease predisposition.
