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As a pure HR-lowering agent, it is a unique medication from a new therapeutic class.
In the future, to our knowledge, exploring a unique medication specific for Lp(a) modulation must be a top priority.
Randomisation was performed using an interactive voice response system which collected patient identifying information by telephone and assigned randomisation numbers linking the patient to a treatment group and specifying a unique medication number for the study drug to be dispensed to the patient.
Some felt that this should be a requirement for all research, while others specified that access to the intervention being studied should only be extended past the end of the study if no other alternatives are available: "…if it's truly a unique medication for a unique problem then there should be some way in which they can get privileged access".
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IVRS assigned a randomisation number to the patient, which was used to link the patient to a treatment arm and to specify unique medication numbers for the first package of study drug to be dispensed to the patient.
Similarly, cystic fibrosis patients have equally unique medication needs, and so the inclusion of an indication parameter in the ADM allows us to focus clinical content just to this specialized population.
Over a 1-year period, Duke University Hospital engaged in the challenging task of enhancing an established computerized provider order entry (CPOE) system to address the unique medication dosing needs of pediatric patients.
Polypharmacy was also common in this group, with the average study participant prescribed a mean of 12.3 (SD = 6.2) unique medications in the year preceding cohort entry.
We used the mean number of unique medications dispensed in the prediagnosis period as a measure of disease burden (14).
We also used the sum of the number of unique medications prescribed in the year preceding index as another measure of medical comorbidity [ 23].
Antibiotics are unique medications and must be prescribed only with good reason.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com