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The phrase "a unique composition" is correct and usable in written English.
It can be used to describe a piece of work, such as music, art, or writing, that is original and distinct from others.
Example: "The artist presented a unique composition that captivated the audience with its innovative style."
Alternatives: "an original piece" or "a distinctive creation".
Exact(48)
Court surface is a unique composition, mainly Maryland bluestone; you can play 10 minutes after a hurricane & 15 minutes after a snowstorm.
The Goldfinch (1654) is one of his best-known works and a unique composition in the tradition of 17th-century Dutch painting.
The GLA planners said: "A building with a unique composition, with a striking roof form and an architectural appearance of the highest order, consistent with the aspirations of the London Plan".
But the building, with original wainscoting, parquet floors and eight fireplaces (each a unique composition of metal, carved wood and ceramics) was hard to put out of their minds.
Similar to other species24,25, our results suggest that healthy M. capitata has a unique composition of endogenous fluorescence (type and arrangement of fluorescent pigments), and that composition is maintained across shallow water habitats.
In comparison to amber inclusions, which show representational bias towards arboreal taxa27, the fossil arthropods of the Quercy localities constitute a unique composition of forest floor communities associated with vertebrate carrion18,23.
Similar(12)
Every tissue has an ECM with unique composition and topology that governs the process of determination, differentiation, proliferation, migration and regeneration of cells.
Every tissue and organ contains an ECM with unique composition that consists of the secreted products of resident cells [ 29].
The viral PSI has a unique gene composition compared to the PSI composition of its hosts.
It is, as M/M (Paris) put it, "a truly unusual and unique composition".
The term shape is used as a generalized conceptualization of model architecture where architecture references the unique composition of a model (i.e. the penetrance values and arrangement of those values across genotypes).
More suggestions(17)
a unique content
a unique establishment
a unique compilation
a unique membership
a unique formation
a specific composition
a distinctive composition
a unique composer
a unique constituent
a particular composition
a peculiar composition
a unique configuration
a unique mix
a unique component
just one composition
its own unique composition
only one composition
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com