Our findings point to a subset of genes with a unique combination of cortical areal expression and evolutionary patterns, suggesting that they play important roles in the transcriptional network underlying human-specific neural traits.
They found that each tissue displays a unique combination of detectable Hox gene expression levels which is altered when normal cells changes to malignant cancer cells [ 26- 28].
These genes display an unusual form of random combinatorial monoallelic expression where each neuron expresses a unique combination of the protocadherin isoforms.
To characterize distinct cell types, neuroscientists take advantage of the fact that many neuronal and glial subsets can be defined by the expression of a unique combination of genes.
Within each tissue, expression of a unique combination of claudins, therefore, determines the respective paracellular tightness of the TJs for different solutes.
However, Eames et al. had proposed that a unique combination of Sox9 and Runx2 may drive the expression of the major marker of hypertrophic chondrocytes, Col10, based on the analysis of Sox9 and Runx2 functions in primary cartilage differentiation of the avian cranial skeleton [ 36].
In the embryonic CNS of Drosophila, neural stem cells (termed neuroblasts, NBs) can be individually identified by their characteristic time and position of delamination from the neuroectoderm (NE), and the expression of a unique combination of molecular markers (Broadus et al., 1995; Doe, 1992; Urbach and Technau, 2003).
These studies suggest that the fate of each partner is determined by cell-type specific transcription factors, which activate expression of a unique combination of cell-surface receptors to permit adhesion only between appropriate partners (Polleux et al., 2007; Sanes and Yamagata, 2009).
"He's a got a unique combination of experiences".
"He is a unique combination of size, skill and toughness.
