Because we know that ccRCC cells are ladened with lipids [4] and that they histologically resemble adipocytes, we further hypothesized that our ccRCC cells may have undergone adipogenic transdifferentiation, a type of mesenchymal differentiation.
A type of trans-differentiation, is the pre-neoplastic but often reversible physiological conversion of a given cell type into another in the context of tissue injury or chronic inflammation.
This approach for enhancing a single type of differentiation is immediately applicable to all areas of tissue engineering.
Of interest, OSPC2, a serous papillary tumour with mixed clear cell features (i.e., a biologically aggressive variant of ovarian cancer characterised by a poor prognosis) clustered on a sub-branch with USPC. Figure 2 shows the cluster analysis on hybridisation intensity values for each gene in 10 primary cultures of OSPC and USPC showing a single type of differentiation.
The mathematical model was based on a "conveyor-belt" [19] type of differentiation and allowed the study of cell fluxes, residence times, and rates of import, export, proliferation, and death across cell compartments for thymocytes and recent thymic emigrants.
In the present study, we hypothesized that an evaluation of the histologic type of differentiation could independently predict the prognosis after periampullary resections and possibly give more precise information about patient prognosis than evaluation of tumour origin.
For multiple reasons, we suggest that determination of the histologic type of differentiation is a useful adjunct to classification of the anatomical site of origin in periampullary tumours.
In contrast, in group three, exposed at age 6 9 years and showing a short latent period, the dominant type of differentiation was papillary (57.1, 95% CI (43.15, 70.94)).
Pancreatobiliary type of differentiation was an adverse predictor of survival both in the whole cohort of periampullary adenocarcinomas (p < 0.001, figure 3A) and in the ampullary subgroup (p < 0.022, figure 3B).
The validity of the final model was tested in the ampullary subgroup, confirming that pancreatobiliary versus intestinal type of differentiation was an independent adverse predictor of survival also among these patients (p < 0.002; HR 4.0; 95% CI 1.6 9.6).
